Análisis del turismo rural comunitario en Colombia y España: estudio de casos.

Esta obra aborda el turismo y su gestión local, denominado para este texto como un turismo comunitario, teniendo en cuenta que son amplias las concepciones teóricas que abordan este concepto. Si bien es verdad que todavía no está muy difundido este término, también es cierto que desde la academia se ha ido posicionando de forma sólida, puesto que refrenda una realidad ya extendida. Así, este turismo rural comunitario es cada vez más seguido por los emprendedores y potenciado por los gobiernos y por las corporaciones locales. No en vano los turistas son más exigentes con las tipologías de ocio que buscan; en este sentido, como ciudadanos concienciados, quieren unas actividades de ocio y esparcimiento que sean responsables con el entorno, cuyo uso en modo alguno condiciona el bienestar de las futuras generacione

Análisis del turismo rural comunitario en Colombia y España: estudio de casos.

Esta obra aborda el turismo y su gestión local, denominado para este texto como un turismo comunitario, teniendo en cuenta que son amplias las concepciones teóricas que abordan este concepto. Si bien es verdad que todavía no está muy difundido este término, también es cierto que desde la academia se ha ido posicionando de forma sólida, puesto que refrenda una realidad ya extendida. Así, este turismo rural comunitario es cada vez más seguido por los emprendedores y potenciado por los gobiernos y por las corporaciones locales. No en vano los turistas son más exigentes con las tipologías de ocio que buscan; en este sentido, como ciudadanos concienciados, quieren unas actividades de ocio y esparcimiento que sean responsables con el entorno, cuyo uso en modo alguno condiciona el bienestar de las futuras generacione

Apolipoprotein C-III in patients with systemic lupus erythematosus

Background: Systemic lupus erythematosus (SLE) has been associated with atherosclerotic cardiovascular disease (CV) and an altered lipid profile. High levels of apolipoprotein C-III (ApoC3) are associated with elevated triglyceride levels and an increased risk of CV. In the present study, we aimed to study circulating ApoC3 in patients with SLE and describe its relationship with the manifestations of the disease. Methods: This is a cross-sectional study that included 186 patients with SLE. Disease-related data, CV comorbidity, full lipid profile, and serum levels of ApoC3 were assessed. A multivariable regression analysis was performed to study how ApoC3 was related to SLE features. Results: Classic CV risk factors were significantly and strongly associated with circulating ApoC3. After a fully multivariable analysis that included classic CV risk factors and lipid profile molecules, SLICC damage (beta coef. 0.10 [95% CI 0.02?0.19] mg/dl, 0.020) and Katz severity (beta coef. 0.11 [95% CI 0.03-0.19] mg/dl, p = 0.011) indices and SLEDAI activity score (beta coef. 0.05 [95% CI 0.05-0.08] mg/dl, p = 0.004) were all independently associated with higher levels of circulating ApoC3. Conclusion: Among SLE patients, disease activity, severity, and disease damage are independently associated with higher ApoC3 serum levels.Funding: This work was supported by a grant to I.F-A. from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013–2016 and by Fondo Europeo de Desarrollo Regional—FEDER—(Fondo de Investigaciones Sanitarias, PI17/00083)

Inhibition of Sema-3A Promotes Cell Migration, Axonal Growth, and Retinal Ganglion Cell Survival

Semaphorin 3A (Sema-3A) is a secreted protein that deflects axons from inappropriate regions and induces neuronal cell death. Intravitreal application of polyclonal antibodies against Sema-3A prevents loss of retinal ganglion cells ensuing from axotomy of optic nerves. This suggested a therapeutic approach for neuroprotection via inhibition of the Sema-3A pathway.Funded by the EU seventh framework program, Grant Agreement #604884.Peer reviewe

Efficient Synthesis of Pseudopeptidic Molecular Cages

Pseudopeptidic cages have been efficiently prepared by combining a dynamic covalent procedure with the suitable preorganization of the building blocks by a conformational bias or an anion templation

Efficient synthesis of pseudopeptidic molecular cages

Pseudopeptidic cages have been efficiently prepared by combining a dynamic covalent procedure with the suitable preorganization of the building blocks by a conformational bias or an anion templation (see figure). © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Financial support from the Spanish MICINN (CTQ2009-14366-C02 project) is gratefully acknowledged.Peer Reviewe

Compuestos para la inhibición de la apoptosis

La presente invención se refiere a compuestos que actúan como inhibidores de la apoptosis, así como a procedimientos para su preparación, a composiciones farmacéuticas que los contienen y a su uso en medicina.Peer reviewedLaboratorios SALVAT SA, Consejo Superior de Investigaciones Científicas (España)T3 Traducción de patente europe

Anti-Tat and anti-HIV activities of trimers of n-alkylglycines

9 pages, 7 figures.Transcription of human immunodeficiency virus (HIV-1) is activated by viral Tat protein which regulates HIV–LTR transcription and elongation. In the present report, the evaluation of the anti-Tat activity of a combinatorial library composed of 5120 N-trialkylglycines is reported. The antiviral activity was studied through luciferase-based assays targeting the HIV-1 promoter activation induced by the HIV-1 Tat protein. We identified five peptoids with specific anti-HIV-1 Tat activity; none of these peptoids affected the binding of HIV-1 Tat protein to the viral TAR RNA. Using a recombinant-virus assay in which luciferase activity correlates with the rate of HIV-1 transcription we have detected that one of the five selected peptoids, NC37-37-15C, is a potent inhibitor of HIV-1–LTR transcription in both primary T lymphocytes and transformed cell lines. The inhibitory effect of NC37-37-15C, which is additive with azidothymidine (AZT), correlates with its ability to inhibit CTD phosphorylation and shows a suitable profile for development of novel anti-HIV-1 drugs. Likewise, the structural simplicity of N-alkylglycine oligomers makes these peptidomimetics amenable to structural manipulation, thus facilitating the optimisation of lead molecules for drug-like properties.This work was supported by Ministerio de Educación y Ciencia Grant SAF2004-00926 and Fondo de Investigación Sanitaria PI040526 to EM, and Ministerio de Ciencia y Tecnología SAF2001-2286 and Fundació Marató TV3 (2004) to AM.Peer reviewe